Determining human-coronavirus protein-protein interaction using machine intelligence.

The Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) virus spread the novel CoronaVirus -19 (nCoV-19) pandemic, resulting in millions of fatalities globally. Recent research demonstrated that the Protein-Protein Interaction (PPI) between SARS-CoV-2 and human proteins is accountable for viral pathogenesis. However, many of these PPIs are poorly understood and unexplored, necessitating a more in-depth investigation to find latent yet critical interactions. This article elucidates the host-viral PPI through Machine Learning (ML) lenses and validates the biological significance of the same using web-based tools. ML classifiers are designed based on comprehensive datasets with five sequence-based features of human proteins, namely Amino Acid Composition, Pseudo Amino Acid Composition, Conjoint Triad, Dipeptide Composition, and Normalized Auto Correlation. A majority voting rule-based ensemble method composed of the Random Forest Model (RFM), AdaBoost, and Bagging technique is proposed that delivers encouraging statistical performance compared to other models employed in this work. The proposed ensemble model predicted a total of 111 possible SARS-CoV-2 human target proteins with a high likelihood factor ≥70%, validated by utilizing Gene Ontology (GO) and KEGG pathway enrichment analysis. Consequently, this research can aid in a deeper understanding of the molecular mechanisms underlying viral pathogenesis and provide clues for developing more efficient anti-COVID medications.

Pandemic disease detection through wireless communication using infrared image based on deep learning.

Rapid diagnosis to test diseases, such as COVID-19, is a significant issue. It is a routine virus test in a reverse transcriptase-polymerase chain reaction. However, a test like this takes longer to complete because it follows the serial testing method, and there is a high chance of a false-negative ratio (FNR). Moreover, there arises a deficiency of R.T.-PCR test kits. Therefore, alternative procedures for a quick and accurate diagnosis of patients are urgently needed to deal with these pandemics. The infrared image is self-sufficient for detecting these diseases by measuring the temperature at the initial stage. C.T. scans and other pathological tests are valuable aspects of evaluating a patient with a suspected pandemic infection. However, a patient's radiological findings may not be identified initially. Therefore, we have included an Artificial Intelligence (A.I.) algorithm-based Machine Intelligence (MI) system in this proposal to combine C.T. scan findings with all other tests, symptoms, and history to quickly diagnose a patient with a positive symptom of current and future pandemic diseases. Initially, the system will collect information by an infrared camera of the patient's facial regions to measure temperature, keep it as a record, and complete further actions. We divided the face into eight classes and twelve regions for temperature measurement. A database named patient-info-mask is maintained. While collecting sample data, we incorporate a wireless network using a cloudlets server to make processing more accessible with minimal infrastructure. The system will use deep learning approaches. We propose convolution neural networks (CNN) to cross-verify the collected data. For better results, we incorporated tenfold cross-verification into the synthesis method. As a result, our new way of estimating became more accurate and efficient. We achieved 3.29% greater accuracy by incorporating the "decision tree level synthesis method" and "ten-folded-validation method". It proves the robustness of our proposed method.

Machine intelligence in dynamical systems: \A state-of-art review

This article is dedicated to study the impact of machine intelligence (MI) methods viz. various types of Neural models for investigating dynamical systems arising in interdisciplinary areas. Different types of artificial neural network (ANN) methods, viz., recurrent neural network, functional-link neural network, convolutional neural network, symplectic artificial neural network, genetic algorithm neural network, and so on, are addressed by different researchers to investigate these problems. Although various traditional methods have been developed by researchers to solve these dynamical problems but the existing traditional methods may sometimes be problem dependent, require repetitions of the simulations, and fail to solve nonlinearity behavior. In this regard, neural network model based methods are more general and solutions are continuous over the given domain of integration, self-adaptive and can be used as a black box. As such, in this article, we have reviewed and analyzed different MI methods, which are applied to investigate these problems. This article is categorized under: Technologies > Computational Intelligence Technologies > Machine Learning Application Areas > Science and Technology

A review and meta-analysis of machine intelligence approaches for mental health issues and depression detection

Cases of mental health issues are increasing continuously and have sped up due to COVID-19. There are high chances of developing mental health issues such as depression, anxiety, schizophrenia, and dementia after 2–3 months of COVID-19 diagnosis. In this paper, a review and meta-analysis of machine intelligence approaches—namely, machine learning, deep learning (deep learning with hybrid boosting), and machine vision methods—for mental health issues and depression detection were presented. Meta-analysis was performed in four parts. The first part focused on the publication trends, criteria for inclusion and exclusion, and the current methodological scenario. The second part was intended for the methods and their advantages and limitations. It covered mental health issues and depression detection techniques along with the challenges. The third part focused on the discussion and applicability of datasets. The fourth part focused on the complete analysis and discussion along with suggestive measures;moreover, it covered the overall analysis, including the methodological impact, result impact, current trends, and some suggestions based on the limitations and challenges. © The Authors.